Table 3.

association of omega 3 intake and the ratio of omega 6 to omega 3 with changes in inflammatory status

Association of Omega-3 with Inflammatory Status
	Quartile of Omega-3 intake
	1 (<0.8 mg/d)	2 (0.8-<1.1 mg/d)	3 (1.1-<1.6 mg/d)	4 (1.6-<3.5 mg/d)
No. of patients	37	36	37	35
CRP change * (mg/dl)	+1.0 (+0.2 to +1.8)	+0.6 (−0.6 to +1.8)	−0.7 (−1.7 to +0.3)	+0.9 (−0.4 to +1.9)

Association of Omega-6 to Omega-3 Ratio with Inflammatory Status
	Quartile of Omega-6 to Omega-3 Ratio
	1 (1.7<7.6)	2 (7.6-<9.3)	3 (9.3-<11.3)	4 (11.3-17.4)
No. of patients	37	36	36	36
CRP change* (mg/dl)	−0.4 (−1.0 to +0.2)	+0.4 (−0.4 to +1.2)	−0.2 (−1.4 to +1.0)	+1.5 (+0.3 to +2.7)

ANCOVA and Correlation Coefficients
	P for ANCOVA	Beta for regression (p-value)
Dietary Omega-3
after adjustment for case-mix**	0.4	−0.58 (0.2)
after adjustment for case-mix and diet	0.7	−0.62 (0.3)
after adjustment for case-mix , diet, BMI,    HTN, and baseline CRP	0.9	−0.58 (0.3)
Dietary Omega-6 to Omega-3 Ratio
after adjustment for case-mix	0.2	+0.52 (0.09)
after adjustment for case-mix and diet	0.1	+0.50 (0.04)
after adjustment for case-mix , diet, BMI,    HTN, and baseline CRP	0.5	+0.55 (0.03)

^*CRP change= CRP after one year minus baseline CRP; values shown are mean (95% confidence interval).

^**Case-mix = age, gender, race/ethnicity, diabetes, dialysis vintage, modified Charlson comorbidity score, dialysis dose (Kt/V); diet, intakes of energy, saturated fat, trans fat, cholesterol and fiber.

Abbreviations and definitions: HTN= history of hypertension; BMI, body mass index; HR, hazard ratio; CI, confidence interval; CRP, C-reactive protein; ANCOVA, analysis of covariance