Table 3.

Long Term Prospective Studies of Large Adult Populations Examining the Depression-CHD Relationship^*

Study	Follow- up Period (years)	Cohort Size (baseline free of CHD)	Mean Age (years)	Women (%)	Minorities (%)	Nonfatal CHD Measure	CHD Death Measure
Brown 2010	15	3767 (2717)	67	68.8	63.4	serum CK-MB > 0.3 ng/ml or serum troponin >0.3 mcg/L	NDI Data
Ahto 2007	12	1196 (715)	71	59	0	N/A	Official Death Registry
Mendes De Leon 1998	9	2488 (2391)	72	60.5	0	discharge diagnosis, serum CK with increase > 4% in MB fraction	Death Certificates

CHD=coronary heart disease, CK-MB=creatine kinase myocardial band isoenzyme, NDI=National Death Index.

^*Follow-up period approaching 10 years, sample size ≥ 1,000 participants, and mean age ≥ 60 years.