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. 2011 Jul 25;194(2):229–243. doi: 10.1083/jcb.201012017

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© 2011 Barnhart et al.

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Figure 8. — HJURP recruitment determines centromere position. (A) HJURP is recruited to centromeres through the action of Mis18. During G1, HJURP directly assembles CENP-A nucleosomes at centromeres along with histones H2A and H2B. The recruitment of HJURP is the critical step in determining the site of the centromere. (B) Redirecting HJURP to an integrated LacO array bypasses the requirement for Mis18, results in deposition of CENP-A, and is sufficient to form a functional kinetochore.