Figure 1.

Progressive α-syn pathology in the limbic areas. Paraffin sections of the cingulate cortex (cing ctx), mammillary body (mam body), molecular layer of the dentate gyrus (DG mol), and hippocampal CA2/3 (hipp CA2/3) areas from the control (A53Tα-syn monogenic) and tTA/A53Tα-syn bigenic mice (n = 6–8 mice per group) (A) and from human DLB patients (n = 4) (B) were stained with anti-syn antibodies, Syn 303 or Syn 1150 (brown), and counterstained with hematoxylin (blue). Hereafter, all the counterstaining is done with hematoxylin unless stated otherwise. Insets in A and B indicate enlarged images of another area with neuritic pathology. Note that most of the accumulated α-syn in the mice shows a dot-like pattern (asterisks), and some shows a neuritic pattern (arrows) at these ages. Scale bars, 20 μm.