Table 2.

Body weight and composition analyses of C57BL6 mice treated for three weeks with DOCA-salt and i.c.v. infusion of either aCSF or losartan (5 ug/hr).

Parameter	Sham + aCSF (N=5)	Sham + Losartan (N=4)	DOCA-salt + aCSF (N=8)	DOCA-salt+ Losartan (N=9)
*Body Masses*
Baseline (g)	25.3 ± 0.4	25.5 ± 0.9	23.4 ± 0.4^*	23.8 ± 0.4^*
Post-Treatment (g)	27.4 ± 0.5	27.0 ± 0.6	25.1 ± 0.6^*	25.9 ± 0.6^*
Delta (g)	2.2 ± 0.9	1.4 ± 0.4	1.8 ± 0.7	2.1 ± 0.6
*Adipose Pads*
Interscapular Brown (mg)	48.5 ± 6.1	65.7 ± 7.4	62.8 ± 5.2	70.0 ± 4.0^*
(mg/g)	1.78 ± 0.25	2.45 ± 0.32	2.50 ± 0.20^*	2.71 ± 0.14^*
Peri-Genital White (mg)	403 ± 36	294 ± 32^*	222 ± 18^*	269 ± 28^*
(mg/g)	14.6 ± 1.2	10.9 ± 1.1^*	8.8 ± 0.6^*	10.5 ± 1.2^† ^*
*Cardiovascular Organs*
Liver (g)	0.96 ± 0.21	1.02 ± 0.07	1.47 ± 0.05^*	1.47 ± 0.05^*
(g/g)	35.2 ± 7.9	37.8 ± 2.4	58.7 ± 2.4^*	57.0 ± 1.2^*
Kidney (mg)	168 ± 3	177 ± 62	227 ± 5^*	233 ± 6^*
(mg/g)	6.1 ± 0.2	6.6 ± 0.3	9.1 ± 0.2^*	9.0 ± 0.1^*
*Serum Electrolytes*
Sodium (mmol/L)	148.6 ± 1.7	157.1 ± 2.2^*	161.3 ± 0.7^*	160.3 ± 0.7^*

P < 0.05 vs. Sham+ aCSF

^†

P < 0.05 vs. DOCA-salt + aCSF

mg/g and g/g indicate normalization to body weight, in grams