Table 4.

The relationship between the endoplasmic reticulum stress-associated molecules, C-CASP3 and matrix gene expressions by chondrocytes in human osteoarthritic cartilage

	C-CASP3		ACAN/GAPDH		COL2A1/GAPDH
	rs	P-value	rs	P-value	rs	P-value
Immunohistochemistry
pPERK (%)	0.52	0.031	−0.73	0.001	0.06	0.822
Ub (%)	0.49	0.039	−0.57	0.015	−0.01	0.953
GRP78 (%)	0.30	0.195	−0.14	0.392	0.38	0.124
CHOP (%)	0.68	0.003	−0.70	0.003	−0.11	0.629
pJNK (%)	0.24	0.308	−0.66	0.005	0.16	0.489
mRNA analysis
Spliced/unspliced XBP1	0.34	0.147	−0.25	0.282	0.01	0.969
CHOP/GAPDH	0.49	0.034	−0.278	0.225	0.026	0.911

r_s, Spearman's rank correlation coefficient; C-CASP3, cleaved caspase-3.