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. 2011 Jul;163(6):1203–1213. doi: 10.1111/j.1476-5381.2010.01124.x

Figure 4.

Figure 4

The depressor effects of nAChRs in the NTS before and after administration of selective nitric oxide synthase inhibitors. (A) Representative traces demonstrate the depressor effects of nicotine (1.5 pmol) in unilateral NTS before and 10 min after pretreatment with L-NIO (6 nmol). (B) Reveals the effects of pretreatment with L-NIO (6 nmol) on MBP and HR after microinjection of nicotine into unilateral NTS. (C) Representative traces demonstrate the depressor effects of nicotine (1.5 pmol) in unilateral NTS before and 10 min after pretreatment with vinyl-L-NIO (600 pmol). (D) Reveals the effects of pretreatment with vinyl-L-NIO (600 pmol) on MBP and HR after microinjection of nicotine into unilateral NTS. Values are shown as mean change ± SEM, n = 6. *P < 0.05 versus control group. BP, blood pressure; EGTA, ethylene glycol tetraacetic acid; HR, heart rate; L-NIO, N(5)-(-iminoethyl)-L-ornithine; MBP, mean blood pressure; nAChRs, nicotinic acetylcholine receptors; NTS, nucleus tractus solitarii; vinyl-L-NIO, N5-(1-Imino-3-butenyl)-L-ornithine.

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