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Proposed phase I and II biotransformation pathway for N-(4-hydroxyphenyl)retinamide (4-HPR). Potential pathways for the interconversion of one metabolite into another, that is, the conversion of N-(4-methoxyphenyl)retinamide (4-MPR) to 4-oxo-N-(4-hydroxyphenyl)retinamide (4-oxo-4-HPR), have been omitted due to the very low/no conversion kinetic parameters observed in HLM and MLM.
