Figure 4.

Effects of potassium channel blockers on serum cytokine levels. Rats were injected with vehicle (PBS or DMSO), tetraethylammonium (TEA; A and C; 8 mg·kg⁻¹; s.c.) or glibenclamide (GLB; B and D; 1 mg·kg⁻¹; s.c.) 4 h after CLP or sham surgery. Twenty hours later, blood samples were collected and assayed for cytokine levels; TNF-α (A and B); IL-1 β (C and D). Each bar represents the mean of 8–10 animals, and vertical lines are SEM. Statistical analyses were performed using two-way anova followed by Newman–Keuls post hoc test. *P < 0.05 significantly different from corresponding sham group and #P < 0.05 significantly different from corresponding CLP rats.