Figure 10.

Effect of NOS-2 inhibitors on NO_x plasma levels. A. Effects of aminoguanidine (AG). B. Effect of 1400W. Rats were treated subcutaneously 12 h after CLP surgery with vehicle or inhibitors as in Figure 9. Twelve hours later, blood samples were collected and assayed for NO_x levels. Each bar represents the mean of 8–10 animals, and vertical lines are SEM. Statistical analyses were performed using two-way anova followed by Newman–Keuls post hoc test. *P < 0.05 significantly different from corresponding sham group and #P < 0.05 significantly different from corresponding CLP rats.