Table 1.
Effects of the early injection of tetraethylammonium (TEA) on blood biochemistry and inflammatory markers in rats after CLP or sham surgery
| Experimental groups | ||||
|---|---|---|---|---|
| Sham | CLP | |||
| PBS | TEA | PBS | TEA | |
| Urea | 217 ± 15 | 222 ± 27 | 390 ± 51* | 247 ± 23# |
| Creatinine | 2.0 ± 0.1 | 2.4 ± 0.4 | 4.4 ± 0.4* | 3.1 ± 0.2*# |
| Lactate | 91 ± 32 | 75 ± 14 | 221 ± 26* | 129 ± 16# |
| Leukocytes | 7.7 ± 0.68 | 8.0 ± 0.45 | 4.6 ± 0.49* | 4.9 ± 0.65* |
| MPO activity | 63 ± 11.6 | 93 ± 4.7 | 202 ± 24.6* | 143 ± 12.1*# |
Rats were injected with TEA (8 mg·kg−1, s.c.) or vehicle (PBS) 4 h after CLP or sham surgery and the variables measured 20 h later. Urea, creatinine and lactate values are expressed as mg L–1; lung myeloperoxidase (MPO) activity is expressed as optical density units (mg protein)−1; total leukocyte numbers are expressed as 103cells mm–3. Data are expressed as mean ± SEM. Statistical analyses were performed using two-way anova followed by Newman–Keuls post hoc test.
*
P < 0.05 significantly different from sham animals
#
P < 0.05 significantly different from CLP animals.