Figure 4.

Compound A blocks αβ-Me-ATP evoked current in cells expressing the human P2X3 receptor. Representative currents recorded from one cell, evoked by an αβ-Me-ATP concentration close to the EC₈₀ value (5 µM, applied for the time indicated by the horizontal bar above each current trace), in the absence (control), in the presence of increasing concentrations of compound A (as indicated above each current trace) and during the wash-out (A). Percentage block of peak current responses were plotted against the logarithm of compound A concentration. Data points were fitted to the four parameter logistic equation. Each data point represents the mean ± SEM from two to four cells (B).