Table 1.
FLIPR assay results for compound A, compound B and compound C assayed against human and rat P2X2/3 and human P2X3, P2X1, P2X2, P2X4 and P2X7 receptors
| Receptor subtype (cell background) | Compound A | Compound B | Compound C |
|---|---|---|---|
| hP2X2/3 (CHO) | 6.68 ± 0.02 (191) | NT | 6.37 ± 0.12 (9) |
| rP2X2/3 (CHO) | 6.04 ± 0.03 (29) | NT | NT |
| hP2X3 (1321N1) | 7.39 ± 0.06 (9) | 6.31 ± 0.09 (9) | 7.24 ± 0.18 (9) |
| hP2X1 (HEK) | <4.7 (17) | <4.7 (6) | <4.7 (5) |
| hP2X2 (1321N1) | <4 (9) | <4 (9) | <4 (9) |
| hP2X4 (CHO) | <5 (4) | <5 (4) | <5 (4) |
| hP2X7 (U2OS) | <4.7 (36) | <4.7 (4) | <4.7 (4) |
Data are mean ± SEM of pIC50 with the number of measurements in parenthesis. NT, not tested.