Table 4.

Multivariable adjusted association between baseline characteristics of diabetic and non-diabetic women and a detectable high sensitivity cardiac troponin (≥0.003 μg/L) at baseline in the Women’s Health Study. Backward selection (p-value threshold of <0.15) was used to choose covariates in separate analyses for diabetic and non-diabetic women. Odds ratios (ORs) and P-values are presented only for those correlates included in the final adjusted model. Models including low density lipoprotein cholesterol (instead of total cholesterol) or history of hypertension (instead of systolic blood pressure) yielded similar results.

	Diabetic Women*		Reference Subcohort of Non-Diabetic Women†
Characteristic	Adjusted Odds Ratio (95% CI)	P-value	Adjusted Odds Ratio (95% CI)	P-value
Age, per 5 year increase	1.21 (1.05-1.41)	0.01	1.30 (1.15-1.47)	<0.0001
Systolic blood pressure, per 10 mmHg increase	1.20 (1.04-1.38)	0.01	1.12 (0.98-1.27)	0.09
Current smoking‡	-		0.43 (0.20-0.94)	0.04
Past smoking‡	-		0.91 (0.61-1.36)	0.20
Total cholesterol (per 1 SD increase)	1.18 (0.99-1.40)	0.07	0.74 (0.60-0.91)	0.005
Hemoglobin A1c (per 1 SD increase)	1.04 (1.01-1.08)	0.01	1.19 (0.98-1.44)	0.07
Natural logarithm of the EGFR (per 1 SD increase)	1.22 (1.01-1.48)	0.04	-
Natural logarithm of NT-proBNP (per 1 SD increase)	1.18 (0.97-1.43)	0.10	-

Abbreviations: EGFR, estimated glomerular filtration rate; NT-proBNP, amino-terminal pro-B-type natriuretic peptide.

^*Of the 512 diabetic women, 233 (45.5%) had a detectable hsTnT.

^†Of the 564 non-diabetic women in the reference subcohort, 171 (30.3%) had a detectable hsTnT.

^‡Past smoking was included in combination with current smoking, such that never smokers were the referent group.