Figure 2. The effect of depolarizing tonic GABA_A conductance on a model neuron.

(a) Sample traces of the cell firing induced by g_GABA. (b) Summary plot of the cell firing frequency versus g_GABA (n=10) (c) Sample traces of the effect of g_GABA on RMP fluctuations set by stochastic channel openings. The Na⁺ channel density was reduced by half compared with panel a to avoid cell firing. (d) Summary plot of RMP (black squares, n=10) and RMP standard deviation (s.d., white squares, n=10) versus g_GABA. (e) Representative traces of membrane potential at different RMPs produced by g_GABA (left panel) and by I_inj (right panel). (f) Summary data of the change in the model cell firing at different RMPs set by g_GABA (empty circles, n=10) and by I_inj (black squares, n=10). (g) Representative traces of membrane potential at different RMPs produced by g_GABA (left panel) and by I_inj (right panel). g_Na was reduced by half to prevent the cell from firing. (h) Mean standard deviation of RMP (s.d.) at different RMPs set by g_GABA (empty circles, n=10) and by I_inj (black squares, n=10). Error bars, s.e.m.