Table 3. Sensitivity and specificity of the software provided classification for detection of the different disease categories, for each parameter, respectively. For the analysis borderline and outside normal limits classifications were grouped together as abnormal results.
|
Normal vs OHT |
Normal vs preperimetric glaucoma |
Normal vs perimetric glaucoma |
Normal vs preperimetric and perimetric glaucoma |
|||||
|---|---|---|---|---|---|---|---|---|
| Sensitivity (%) (95% CI) | Specificity (%) (95% CI) | Sensitivity (%) (95% CI) | Specificity (%) (95% CI) | Sensitivity (%) (95% CI) | Specificity (%) (95% CI) | Sensitivity (%) (95% CI) | Specificity (%) (95% CI) | |
| Main RNFLT parameters (μm) | ||||||||
| Average | 8.3 (0.5–63.0) | 100.0 (96.0–100.0) | 34.8 (16.6–58.9) | 100.0 (96.0–100.0) | 83.8 (75.0–89.9) | 100.0 (96.0–100.0) | 69.4 (60.2–77.3) | 100.0 (96.0–100.0) |
| Superior | 8.3 (0.5–63.0) | 100.0 (96.0–100.0) | 37.0 (18.5–60.2) | 100.0 (96.0–100.0) | 78.4 (68.6–85.7) | 100.0 (96.0–100.0) | 66.2 (56.7–74.6) | 100.0 (96.0–100.0) |
| Inferior | 5.6 (0.2–69.4) | 97.8 (92.4–99.4) | 23.9 (7.9–53.4) | 97.8 (92.4–99.4) | 83.8 (75.0–89.9) | 97.8 (92.4–99.4) | 66.2 (56.7–74.6) | 97.8 (92.4–99.4) |
| RNFLT sectors (μm) | ||||||||
| TU1 | 2.8 (0.0–80.5) | 94.6 (87.8–97.7) | 13.0 (2.0–53.0) | 94.6 (87.8–97.7) | 67.6 (56.3–77.1) | 94.6 (87.8–97.7) | 51.6 (40.9–62.2) | 94.6 (87.8–97.7) |
| TU2 | 5.6 (0.2–69.4) | 96.8 (90.8–98.9) | 32.6 (14.7–57.6) | 96.8 (90.8–98.9) | 74.8 (64.5–82.9) | 96.8 (90.8–98.9) | 62.4 (52.5–71.4) | 96.8 (90.8–98.9) |
| ST2 | 8.3 (0.5–63.0) | 95.7 (89.3–98.3) | 37.0 (18.5–60.2) | 95.7 (89.3–98.3) | 76.6 (66.5–84.3) | 95.7 (89.3–98.3) | 65.0 (55.3–73.5) | 95.7 (89.3–98.3) |
| ST1 | 5.6 (0.2–69.4) | 96.8 (90.8–98.9) | 17.4 (3.9–52.0) | 96.8 (90.8–98.9) | 65.8 (54.3–75.6) | 96.8 (90.8–98.9) | 51.6 (40.9–62.2) | 96.8 (90.8–98.9) |
| SN1 | 2.8 (0.0–80.5) | 100.0 (96.0–100.0) | 19.6 (5.1–52.2) | 100.0 (96.0–100.0) | 31.5 (18.6–48.1) | 100.0 (96.0–100.0) | 28.0 (16.9–42.6) | 100.0 (96.0–100.0) |
| SN2 | 0.0 (0.0–9.7) | 100.0 (96.0–100.0) | 15.2 (2.9–52.2) | 100.0 (96.0–100.0) | 40.5 (27.5–55.1) | 100.0 (96.0–100.0) | 33.1 (21.9–46.7) | 100.0 (96.0–100.0) |
| NU2 | 2.8 (0.0–80.5) | 100.0 (96.0–100.0) | 8.7 (0.7–57.2) | 100.0 (96.0–100.0) | 35.1 (22.1–50.8) | 100.0 (96.0–100.0) | 27.4 (16.3–42.1) | 100.0 (96.0–100.0) |
| NU1 | 0.0 (0.0–9.7) | 100.0 (96.0–100.0) | 10.9 (1.2–54.5) | 100.0 (96.0–100.0) | 39.6 (26.6–54.4) | 100.0 (96.0–100.0) | 31.2 (20.0–45.1) | 100.0 (96.0–100.0) |
| NL1 | 0.0 (0.0–9.7) | 100.0 (96.0–100.0) | 6.5 (0.3–61.6) | 100.0 (96.0–100.0) | 39.6 (26.6–54.4) | 100.0 (96.0–100.0) | 29.9 (18.8–44.1) | 100.0 (96.0–100.0) |
| NL2 | 0.0 (0.0–9.7) | 97.8 (92.4–99.4) | 8.7 (0.7–57.2) | 97.8 (92.4–99.4) | 27.0 (14.4–44.8) | 97.8 (92.4–99.4) | 21.7 (11.1–38.0) | 97.8 (92.4–99.4) |
| IN2 | 0.0 (0.0–9.7) | 98.9 (94.1–99.8) | 10.9 (1.2–54.5) | 98.9 (94.1–99.8) | 19.8 (8.3–40.3) | 98.9 (94.1–99.8) | 17.2 (7.4–35.2) | 98.9 (94.1–99.8) |
| IN1 | 8.3 (0.5–63.0) | 98.9 (94.1–99.8) | 15.2 (2.9–52.2) | 98.9 (94.1–99.8) | 46.8 (34.0–60.2) | 98.9 (94.1–99.8) | 37.6 (26.3–50.3) | 98.9 (94.1–99.8) |
| IT1 | 19.4 (4.3–56.2) | 97.8 (92.4–99.4) | 30.4 (12.9–56.4) | 97.8 (92.4–99.4) | 88.3 (80.4–93.3) | 97.8 (92.4–99.4) | 71.3 (62.4–78.9) | 97.8 (92.4–99.4) |
| IT2 | 8.3 (0.5–63.0) | 95.7 (89.3–98.3) | 32.6 (14.7–57.6) | 95.7 (89.3–98.3) | 79.3 (69.7–86.4) | 95.7 (89.3–98.3) | 65.6 (56.0–74.1) | 95.7 (89.3–98.3) |
| TL2 | 2.8 (0.0–80.5) | 95.7 (89.3–98.3) | 10.9 (1.2–54.5) | 95.7 (89.3–98.3) | 47.7 (34.9–60.9) | 95.7 (89.3–98.3) | 36.9 (25.7–49.8) | 95.7 (89.3–98.3) |
| TL1 | 5.6 (0.2–69.4) | 94.6 (87.8–97.7) | 8.7 (0.7–57.2) | 94.6 (87.8–97.7) | 51.4 (38.7–63.8) | 94.6 (87.8–97.7) | 38.9 (27.6–51.4) | 94.6 (87.8–97.7) |
| GCC parameters | ||||||||
| Average (μm) | 8.3 (0.5–63.0) | 98.9 (94.1–99.8) | 15.2 (2.9–52.2) | 98.9 (94.1–99.8) | 74.8 (64.5–82.9) | 98.9 (94.1–99.8) | 57.3 (47.0–67.0) | 98.9 (94.1–99.8) |
| Superior (μm) | 5.6 (0.2–69.4) | 98.9 (94.1–99.8) | 6.5 (0.3–61.6) | 98.9 (94.1–99.8) | 71.2 (60.4–80.0) | 98.9 (94.1–99.8) | 52.2 (41.6–62.7) | 98.9 (94.1–99.8) |
| Inferior (μm) | 13.9 (1.9–57.3) | 98.9 (94.1–99.8) | 17.4 (3.9–52.0) | 98.9 (94.1–99.8) | 80.2 (70.7–87.1) | 98.9 (94.1–99.8) | 61.8 (51.8–70.8) | 98.9 (94.1–99.8) |
| FLV (%) | 22.2 (5.9–56.6) | 89.1 (80.6–94.2) | 21.7 (6.5–52.7) | 89.1 (80.6–94.2) | 92.8 (86.1–96.4) | 89.1 (80.6–94.2) | 72.0 (63.1–79.4) | 89.1 (80.6–94.2) |
| Optic nerve head parameters | ||||||||
| Cup area (mm2) | 27.8 (9.6–58.3) | 76.3 (65.3–84.7) | 73.9 (57.3–85.7) | 76.3 (65.3–84.7) | 85.6 (77.1–91.3) | 76.3 (65.3–84.7) | 82.2 (74.7–87.8) | 76.3 (65.3–84.7) |
| Cup/disc area ratio | 27.8 (9.6–58.3) | 72.0 (60.3–81.4) | 76.1 (59.8–87.2) | 72.0 (60.3–81.4) | 87.4 (79.3–92.6) | 72.0 (60.3–81.4) | 84.1 (76.9–89.3) | 72.0 (60.3–81.4) |
| Rim area (mm2) | 27.8 (9.6–58.3) | 76.3 (65.3–84.7) | 73.9 (57.3–85.7) | 76.3 (65.3–84.7) | 85.6 (77.1–91.3) | 76.3 (65.3–84.7) | 82.2 (74.7–87.8) | 76.3 (65.3–84.7) |
Abbreviations: RNFLT, retinal nerve fibre layer thickness; GCC, ganglion cell complex; FLV, focal loss volume; RNFLT sectors: TU, temporal upper; ST, supero-temporal; SN, supero-nasal; NU, nasal upper; NL, nasal lower; IN, infero-nasal; IT, infero-temporal; TL, temporal lower.