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. Author manuscript; available in PMC: 2012 May 13.
Published in final edited form as: Circ Res. 2011 May 13;108(10):1284–1297. doi: 10.1161/CIRCRESAHA.110.233056

Figure 1. Assembly of coagulation complexes on a PS+ phospholipid membrane.

Figure 1

Coagulation complexes (TF:FVIIa; FVIIIa:FIXa; and FVa:FXa) assemble on a membrane surface. The presence of anionic phospholipids, such as PS (red), facilitate the binding of FVIIa, FIXa, FXa, and prothrombin (PT) by interaction with the Gla domains within the proteins. Phospholipids originating from the outer membrane before disruption of membrane asymmetry are shown in grey.