Figure 4. Role of TF⁺ MPs in microvascular and venous thrombosis.

A. Microvascular thrombosis in healthy mice. Leukocyte-derived TF⁺ MPs and vessel wall TF both appear to contribute to thrombosis induced by laser injury to cremaster arterioles. B. Cancer associated venous thrombosis. Tumors release TF⁺ MPs into the circulation where they are proposed to bind to activated endothelium and trigger venous thrombosis.