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Exposure of purified bovine brain tubulin to the vinca alkaloid vincristine sulfate sulfate impairs tubulin polymerization in a concentration-dependent manner. Exposure to 0.1 or 10 μM vincristine sulfate reduced tubulin polymerization by 50–100% at each time point examined for 45 min, though inhibition of tubulin polymerization was significantly greater with exposure to 10 μM vincristine sulfate. *P<0.05 vs. tubulin for each concentration of vincristine at all timepoints measured
