Skip to main content
. Author manuscript; available in PMC: 2011 Jul 27.
Published in final edited form as: Neurochem Res. 2011 Jan 23;36(5):819–828. doi: 10.1007/s11064-011-0409-2

Fig. 5.

Fig. 5

Exposure to recombinant Tat(1-86) (100 nM) produced significant loss of MAP-2(a,b) immunoreactivity in the granule cell layer of the dentate gyrus and pyramidal cell layers of the CA3 and CA1 regions, with no significant treatment × time interactions noted in any region. Co-exposure to Trolox (500 μM) significantly amelio-rated MAP-2(a,b) loss in organotypic hippocampal cultures. Trolox alone did not affect MAP-2(a,b) immunoreactivity in any hippocampal region at any timepoint. The dashed line represents control values. *P<0.001 vs. control; **P<0.001 vs. Tat