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. 2011 Jul 6;31(27):9885–9894. doi: 10.1523/JNEUROSCI.1750-11.2011

Figure 4.

Figure 4.

Intra-VTA infusion of GDNF inhibits expression of CPP to alcohol. A, Design and schedule of place conditioning experiment testing the effects of GDNF on expression of alcohol-CPP: alcohol (0.5 g/kg, 15% v/v) or saline (Sal) was administered intraperitoneally immediately before the 7 min conditioning paired sessions. Saline was administered before the conditioning unpaired sessions. GDNF (10 μg/μl/side) or vehicle (PBS) was infused into the VTA 10 min before the test session. B, Place preference for alcohol expressed as the ratio ± SEM of the time spent in the alcohol-paired and unpaired compartment during the entire session. C, D, Place preference to alcohol expressed as the ratio ± SEM of the time spent in the alcohol-paired and unpaired compartment by blocks of 5 min for the alcohol-vehicle (C) or the alcohol-GDNF (D) conditions. n = 7–9. *p < 0.05; **p < 0.01.