Fasting blood glucose level (mg/dL) | |||||
---|---|---|---|---|---|
Group | Dose | Day 0 | Day 5 | Day 10 | Day 15 |
I (Normal control) | 5 mL/kg | 75.22±3.2 | 74.32±2.3 | 76.81±3.5 | 78.40±1.7 |
II (STZ) | 65 mg/kg | 261.54±10.2* | 275.35±9.8* | 283.21±12.62* | 296.72±10.6* |
III (STZ+MECI) | 250 mg/kg | 258.23±10.7 | 145.58±8.6† | 112.45±2.4† | 96.42±2.5† |
IV (STZ+MECI) | 500 mg/kg | 260.76±6.4 | 97.37±3.4† | 86.22±2.1† | 75.52±3.8† |
V (STZ+Gliben) | 0.5 mg/kg | 266.33±7.3 | 95.96±6.8† | 84.33±3.4† | 74.56±3.5† |
Values are expressed as mean ± standard error of the mean (n=6).
*P<0.001 compared with normal control.
†P<0.001 compared with STZ control.
Gliben=glibenclamide; STZ=streptozotocin.