| Group | Dose | SGOT (IU/L) | SGPT (IU/L) | Total serum protein (g/dL) | SALP (U/L) | Serum cholesterol (mg/dL) |
|---|---|---|---|---|---|---|
| I(Normal control) | 5 mL/kg | 20.24±5.6 | 23.62±4.7 | 6.52±2.6 | 171.22±12.0 | 155.76±8.4 |
| II (STZ) | 65 mg/kg | 36.5± 4.2* | 39.41±5.2* | 3.41±1.7* | 243.5±12.5* | 224.5±12.4* |
| III (STZ+MECI) | 250 mg/kg | 28.9±3.4† | 29.5±3.4† | 5.78±2.8† | 206.56±11.2† | 182.8±11.2† |
| IV (STZ+MECI) | 500 mg/kg | 22.5±3.5† | 24.62±3.5† | 6.60±3.8† | 177.6±14.9† | 159.54±10.3† |
| V (STZ+Gliben.) | 0.5 mg/kg | 22.34±2.4† | 25.32±3.6† | 6.23±3.45†174.82±10.6† | 174.82±10.6† | 162.21±11.2† |
Values are expressed as mean ± standard error of the mean (n=6).
*P<0.001 compared with normal control.
†P<0.001 compared with STZ control group.
Gliben=glibenclamide; SALP=serum alkaline phosphatase; SGOT=serum glutamate oxaloacetate transaminase; SGPT= serum glutamate pyruvate transaminase; STZ=streptozotocin.