Group | Dose | TBARS (mM/100 g wet liver tissue) | GSH (mg/100 g wet liver tissue) | CAT (μmol H 2 O 2 consumed/min/mg wet liver tissue) |
---|---|---|---|---|
I (Normal control) | 5 mL/kg | 1.16±0.4 | 43.32±1.5 | 82.18±3.5 |
II (STZ) | 60 mg/kg | 2.05±0.3* | 24.16±1.4* | 45.38±4.1* |
III (STZ+MECI) | 250 mg/kg | 1.32±0.41† | 35.21±1.2† | 68.39±5.6† |
IV (STZ+MECI) | 500 mg/kg | 1.18±0.52† | 40.12±1.1† | 78.42±3.8† |
V (STZ+Gliben) | 0.5 mg/kg | 1.17±0.41† | 41.08±1.2† | 80.49±4.8† |
Values are expressed as mean ± standard error of the mean (n=6).
*P<0.001 compared with normal control.
†P<0.001 compared with STZ control group.
CAT=catalase; Gliben=glibenclamide; GSH=reduced glutathione; TBARS=thiobarbituric acid reactive substances; STZ=streptozotocin.