Table 3. RMSD to server models.

Web-server	RMSD	Interface RMSD	Coverage %
3D-JIGSAW [53]	6.63 Å	2.14 Å	100%
Consensus Server [54]	5.41 Å	2.03 Å	82%
CPH [55]	5.4 Å	1.89 Å	78%
ESyPred3D [56]	3.66 Å	1.65 Å	85%
SWISS-MODEL [57]	5.24 Å	2.78 Å	78%
Phyre [58]	3.78 Å	1.49 Å	85%

PfSUB1 models were built using several available homology modeling servers. The models obtained with ESyPred3D and Phyre servers are the structurally closest to our model of PfSUB1 with respectively a RMSD of 3.66 Å and 3.78 Å. The interface RMSD were calculated on the residues (see Materials and Methods) that defines the binding pocket. The coverage refers to the percentage of our model structure that was covered by other servers.