Table 2. Results of in vitro enzyme inhibition assay tests.
COX-1 [%] | COX-2 [%] | |||||||||||
ID | 1 | 10 | 100 | 1 | 10 | 100 | ||||||
6± | 2.0 | 9± | 4.2 | 15± | 1.6 | 19± | 2.1 | 23± | † | 17± | 3.2 | |
−3± | 3.5 | −5± | 1.0 | 26± | 23.5 | 14± | 9.7 | 9± | 2.2 | 6± | 1.6 | |
8± | 1.3 | 12± | 3.5 | 10± | 5.1 | 19± | 0.7 | 10± | 1.9 | 14± | 0.1 | |
6± | 10.7 | −6± | 3.8 | −2± | 2.8 | 3± | 3.2 | 3± | 7.4 | −1± | 9.9 | |
7± | 3.9 | 31± | 3.8 | 72± | 4.5 | 27± | 8.1 | 27± | 1.4 | 38± | 3.7 | |
16± | 4.7 | 18± | 9.3 | 15± | 1.6 | 19± | † | 0± | 10.0 | 12± | 2.9 | |
2± | 4.5 | 4± | 8.4 | 7± | † | 20± | 9.4 | 13± | 8.8 | 15± | 0.3 | |
2± | 4.5 | 29± | 26.8 | 16± | 8.0 | 14± | 2.6 | 8± | 2.1 | 11± | 6.2 | |
6± | 16.8 | 46± | 6.1 | 89± | 1.0 | 9± | 0.7 | 24± | 7.6 | 38± | 3.1 | |
−7± | 1.6 | −10± | 8.5 | 7± | 2.8 | 2± | 5.5 | −2± | 2.7 | −1± | 3.7 | |
11± | 12.6 | 5± | 0.6 | 1± | 1.5 | 5± | 2.9 | 4± | 4.2 | 0± | 1.1 | |
18± | 4.0 | 8± | 4.5 | 14± | 1.5 | 15± | 0.1 | 15± | 7.5 | 19± | 2.2 |
Primed () compounds are shown in Fig. 8, starred () compounds are shown in Fig. 9. Discussed compounds are shown in bold face.
For these three measurements, high standard deviations were observed. This could be due to solubility problems, impurities, protein degradation, or other unspecific effects. The corresponding measurements should be treated carefully.