Table 2. QTLs linked to biomechanics and DXA phenotypes in male and female F2 rats. Suggestive QTLs are reported if overlapping a significant QTL.

					LOD scores
	Chr	QTL region	Position (cM)	Phenotype	Male (n = 108)	Cross 1 (n = 66)	Cross 2 (n = 42)
Biomechanics	15	D15Rat109-D15Mit2	10–32	Ult force	1.8	3.9b , c	0.2
DXA	2	D2Mit24-D2Mgh5	45–59	BMC	2.2	0.4	2.8a
	2	D2Mit24-D2Mgh5	45–57	aBMD	2.5a	0.8	4.7b , d
	6	D6Mgh11-D3Mit19	25–58	BMC	2.5a	0.8	4.8b , d
	6	D6Mgh11-D3Mit19	30–60	Area	2.8a	1.3	3.1a
	8	D8Mit3-D8Mit2	35–58	BMC	4.1b	1.3	2.9a
	8	D8Mit2-D8Mgh4	43–59	Area	4.7b	1.4	3.3a

QTL size defined as the region covered by a 1-LOD reduction for any of the bone traits.

^aGenome-wide suggestive QTL (LOD≥2.3).

^bGenome-wide significant QTL (LOD≥3.8).

^cSuggestive cross-specific QTLs (ΔLODcross≥2.4) validated by likelihood ratio (LR) tests for QTL-by-cross interaction (p<0.05).

^dSignificant cross-specific QTLs (ΔLODcross≥3.9) validated by likelihood ratio (LR) tests for QTL-by-cross interaction (p<0.05).