Figure 2. Protection of mice by Ad5-mediated prophylactic therapy and vaccination against a higher dose of PR8 challenge.

AdNC/in/-47, i.n. administration of AdNC.H1.1 on day -47; AdE/in/-47, i.n. administration of AdE on day -47; AdE/in/-47-2, i.n. administration of AdE on day -47 followed by a booster application of day -2; AdE/in/-1, i.n. administration of AdE on day -1; wtAd/in/-1, i.n. administration of E1⁺/E3⁺ wild-type Ad5 particles on day -1; all groups were inoculated with Ad5 particles at a dose of 1.2×10⁸ ifu followed by challenge with 10xLD₅₀ of PR8 on day 0; body weights were recorded daily for 14 days post-challenge; other symbols and protocols are the same as those described in Fig. 1 legend.