Figure 6. Protection against lethal challenge by the pandemic CA04 in mice.

AdE or AdNC.H1.1 particles (2.5×10⁸ ifu per 50 µl) were i.n. instilled into mice at varying time points followed by CA04 challenge. AdE/in/-22, i.n. administration of AdE on day -22; AdNC/in/-22, i.n. administration of AdNC.H1.1 on day -22; placebo control, i.n. administration of 50 µl saline on day -22; animals were challenged by i.n. instillation of 3xLD₅₀ of the pandemic CA04 on day 0; other symbols and protocols are the same as those described in Fig. 1 legend.