Figure 5. FK866 and HDAC inhibitors synergistically kill primary B-CLL cells.
Primary B-CLL cells were incubated with or without FK866 at the indicated concentrations for 48 h. Thereafter, VA or vorinostat were added at the indicated concentrations. Viability was assessed 48 h later by PI cell staining and flow cytometry. CI values refer to the highest drug concentrations used. CICTs for each drug combination are presented in the lower insets.