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. 2011 Jul 27;6(7):e22957. doi: 10.1371/journal.pone.0022957

Figure 5. Phylogenetic evolution of Japanese flounder conserved miRNA families.

Figure 5

(A) Phylogenetic distribution of Japanese flounder conserved miRNA families. A plus (+) symbol represents this miRNA family exists in the species named on the left, and a minus (−) symbol means it is absent in that species. (B) A clade-specific conserved miRNA based on sequence substitutions. The green nucleotides indicate the positions that are the same among the other vertebrates but different from fish, which are shown in red. (C) A flounder-specific conserved miRNA based on sequence substitution. The red nucleotide shows a Japanese flounder-specific position that is different from any other fish. Asterisks indicate the conserved sites among fish. bfl, Branchiostoma floridae; bmo, Bombyx mori; cel, Caenorhabditis elegans; dme, Drosophila melanogaster. has-miR-21, Homo sapiens microRNA 21; mmu-miR-21, Mus musculus microRNA 21; gga-miR-21, Gallus gallus microRNA 21; dre-miR-21, Danio rerio microRNA 21; fru-miR-21, Takifugu rubripes microRNA 21; tni-miR-21, Tetraodon nigroviridis microRNA 21; pol-miR-21, Paralichthys olivaceus microRNA 21.