Table 4.
Distributions of allele and genotype frequencies of FABP4 SNPs as a function of the presence or absence of OSA and obesity.
| Group 1 | Group 2 | 1 vs. 2 | Group 3 | Group 4 | 3 vs. 4 | 1 vs. 3 | 2 vs. 4 | ||
|---|---|---|---|---|---|---|---|---|---|
| SNPs | Genotype | NOB-NOSA (n=90; %) | NOB-OSA (n=92; %) | p value | OB-NOSA (n=33; %) | OB-OSA (n=94; %) | p value | p value | p value |
| rs105135 | GG | 77 (85.6) | 58 (64.4) | 0.003 | 13 (39.4) | 30 (31.9) | 0.47 | <0.001 | <0.001 |
| AA | 4 (4.4) | 15 (16.7) | 6 (18.2) | 27 (28.7) | |||||
| Both | 9 (10) | 17 (18.9) | 14 (42.4) | 37 (39.4) | |||||
| rs2303519 | CC | 73 (81.1) | 62 (68.1) | 0.05 | 17 (51.5) | 64 (68.1) | 0.89 | 0.001 | 0.99 |
| Both | 17 (18.9) | 29 (31.9) | 16 (48.5) | 30 (31.9) | |||||
| rs16909233 | GG | 76 (84.4) | 67 (72.8) | 0.06 | 20 (60.6) | 70 (74.5) | 0.13 | 0.005 | 0.79 |
| Both | 14 (15.6) | 25 (27.2) | 13 (39.4) | 24 (25.5) | |||||
| rs7821186 | AA | 53 (63.1) | 46 (56.8) | 0.62 | 21 (67.7) | 57 (68.7) | 0.59 | 0.64 | 0.22 |
| GG | 8 (9.5) | 11 (13.6) | 4 (12.9) | 6 (7.2) | |||||
| Both | 23 (27.4) | 24 (29.6) | 6 (19.4) | 20 (24.1) | |||||
| rs16909187 | GG | 63 (75) | 51 (62.9) | 0.03 | 23 (74.2) | 58 (69.1) | 0.46 | 0.52 | 0.06 |
| AA | 3 (3.6) | 0 (0) | 0 (0) | 4 (4.8) | |||||
| Both | 18 (21.4) | 30 (37.0) | 8 (25.8) | 22 (26.2) | |||||
| rs16909192 | AA | 67 (79.8) | 57 (70.4) | 0.09 | 23 (74.2) | 60 (73.2) | 0.68 | 0.46 | 0.29 |
| CC | 2 (2.4) | 0 (0) | 0 (0) | 2 (2.4) | |||||
| Both | 15 (17.9) | 24 (29.6) | 8 (25.8) | 20 (24.4) | |||||
| rs10808846 | CC | 43 (51.8) | 30 (37.9) | 0.14 | 15 (48.4) | 36 (43.9) | 0.63 | 0.93 | 0.44 |
| AA | 11 (13.3) | 18 (22.8) | 4 (12.9) | 7 (8.5) | |||||
| Both | 29 (34.9) | 31 (39.2) | 12 (38.7) | 39 (47.6) | |||||
| rs7018409 | GG | 64 (76.2) | 52 (64.2) | 0.03 | 23 (74.2) | 59 (71.1) | 0.46 | 0.48 | 0.05 |
| AA | 3 (3.6) | 0 (0) | 0 (0) | 4 (4.8) | |||||
| Both | 17 (20.2) | 29 (35.8) | 8 (25.8) | 20 (24.1) | |||||
| rs2290201 | TT | 40 (47.6) | 28 (35) | 0.22 | 14 (45.2) | 36 (43.4) | 0.93 | 0.52 | 0.13 |
| CC | 17 (20.2) | 23 (28.7) | 4 (12.9) | 13 (15.7) | |||||
| Both | 27 (32.1) | 29 (36.3) | 13 (41.9) | 34 (40.9) | |||||
| rs6992708 | GG | 11 (13.1) | 15 (18.5) | 0.18 | 4 (12.9) | 9 (10.8) | 0.95 | 0.82 | 0.29 |
| AA | 43 (51.2) | 30 (37.0) | 14 (45.2) | 38 (45.8) | |||||
| Both | 30 (35.7) | 36 (44.4) | 13 (41.9) | 36 (43.4) |