Figure 1.
(A) Aldose reductase (AR) (nmols/min/mg prot) and sorbitol dehydrogenase (SDH) (IU/mg prot) activity; (B) Protein expression of AR and SDH; and (C) concentration of polyol pathway products sorbitol and fructose in perfused hearts from young (n=6) and old (n=6) Fischer 344 rat hearts subjected to normoxic perfusion (4 mos vs. 24 mos of age, respectively).