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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Exp Gerontol. 2011 May 10;46(9):762–767. doi: 10.1016/j.exger.2011.05.001

Figure 2.

Figure 2

(A) Creatine kinase (CK) release during 60 min of reperfusion, a marker of myocardial I/R injury in hearts from young, old, Old-ARI treated (Old-ARI) or Old-SDI treated (Old-SDI) Fischer 344 rats. Pre-ischemic CK release data for young (Pre-Isc-Y) and old (Pre-Isc-O) presented reveal no basal differences in aged vs. young rat hearts. (B) Left ventricular developed pressure (LVDP) recovery in the above hearts. (C) Myocardial ATP content in young, old, old-ARI treated (Old-ARI) or old-SDI treated (old-SDI) Fischer 344 rats. * p<0.05 vs. young in their respective ischemia or reperfusion group. All hearts were subjected to global ischemia followed by reperfusion. ARI = zopolrestat; 1 µM and SDH = CP-470,711, 200 nM. n=6 per group

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