Table 2.

Aldose reductase levels and activity in rat and mice hearts

Group	AR protein (ng/mg total prot)	AR activity (nmols NADPH/min/mg prot)
Fisher 344 RATS
Young rats (n=5)	256 ± 51	2.66 ± 0.32
Old rats (n=5)	540 ± 62*	5.21 ± 0.61#
C57BL6 MICE
Wild Type mice (Young n=8)	98 ± 21	0.66 ± 0.23
Wild Type mice (Old,n=6)	122 ± 52	1.21 ± 0.33
TghAR mice (Young,n=9)	456 ± 49@	4.12 ± 0.81$
TghAR mice (Old mice, n=5)	598 ± 25**	6.89 ± 0.31**

^*p<0.03 vs. young rats

^#p<0.04 vs. young rats

^@p<0.05 vs. young mice

^$p<0.05 vs. young and old mice

^**p<0.05 vs. young TghAR mice