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. Author manuscript; available in PMC: 2011 Sep 15.
Published in final edited form as: Int J Cancer. 2011 Mar 4;129(6):1425–1434. doi: 10.1002/ijc.25814

Figure 1.

Figure 1

Formation of carboplatin–DNA damage. The first step of the carboplatin and DNA interaction is the formation of carboplatin–DNA monoadducts in which only one bond is formed between Pt and DNA. Monoadducts can further react to form interstrand or intrastrand crosslinks (diadducts) in which the leaving group is irreversibly lost. The 14C label (asterisk) is located at the leaving group, which is displaced from the Pt–DNA complex upon repair or crosslink formation. Therefore, AMS can only measure carboplatin–DNA monoadducts from purified DNA.