Skip to main content
. Author manuscript; available in PMC: 2011 Sep 15.
Published in final edited form as: Int J Cancer. 2011 Mar 4;129(6):1425–1434. doi: 10.1002/ijc.25814

Figure 2.

Figure 2

Pathways leading to chemotherapy-induced cell death and resistance. A broad overview of Pt-based cytotoxicity and cellular resistance is shown in this diagram in sequential order. DNA damage is the critical step in the cytotoxic response. Cells with low chemotherapy-induced DNA damage will survive chemotherapy and are chemoresistant. Besides DNA damage, other steps, such as drug metabolism, cell uptake and efflux of drug, intracellular inactivation and DNA repair can also affect the levels of drug–DNA damage.