Group discrimination between relapsing and sustained remission patients, using peak MPFC and calcarine ROI signal change scores, and the difference score between MPFC and calcarine % signal change. Panel A: The proposed cutoff score as calculated by ROC analysis is 0% signal change for the MPFC, yielding 90% sensitivity and 83% specificity. Panel B: for the calcarine ROI the proposed cutoff score is -.1% signal change, yielding 80% sensitivity and 83% specificity for predicting sustained remission. Panel C: Combining both measures by calculating a difference score between MPFC and calcarine ROI % signal change improves prediction accuracy; at the proposed difference cutoff score of 0% signal change, 100% sensitivity and 83% specificity in predicting relapse was observed.