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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Nat Genet. 2011 Jun 26;43(8):768–775. doi: 10.1038/ng.865

Figure 3. Loss of methylation stability at small DMRs.

Figure 3

Methylation estimates plotted against genomic location for normal samples (blue) and cancer samples (red). The small DMR locations are shaded pink. Grey bars indicate the location of blocks, CpG islands, and gene exons. Tick marks along the bottom axis indicate the location of CpGs. Pictured are examples of (a) a methylation boundary shift outward, (b) a methylation boundary shift inward, (c) a loss of methylation boundary, and (d) a novel hypomethylation DMR.