Table 1.
Antibiotic resistance genes most commonly found in LAB
| Antibiotic (pharmacological class) | Resistance gene(s) | Mechanism of action | References |
|---|---|---|---|
|
Tetracycline (Tetracyclines) |
tet(M), (S), (O), (W), (36) | Ribosomal protection | (Roberts 2005); (Thaker et al. 2010) |
| tet(L) | Efflux | (Roberts 2005); (Thaker et al. 2010) | |
| tet(K) | Efflux | (Roberts 2005); (Thaker et al. 2010) | |
|
Erythromycin (Macrolides) |
erm(A), (B), (C), (F), (G) | rRNA Methylases | (Roberts 2008); (Mayrhofer et al. 2010) |
| msr(A/B), (D) | Efflux | (Roberts 2008); (Toomey et al. 2010) | |
| isa(A) | Efflux | (Roberts 2008) | |
| vga(B) | Efflux | (Roberts 2008) | |
|
Vancomycina (Glycopepdtides) |
van(A), (B), (D), (E), (G), (L)b | Peptidoglycan modification | (Werner et al. 2008) |
| van(C)c | Peptidoglycan modification | (Werner et al. 2008) |
aSome LAB genera (Lactobacillus, Pediococcus, Leuconostoc) are intrinsically resistant to Vancomycin
bAcquired
cIntrinsic