Figure 1.
(A) Plasma monocyte chemoattractant protein–1 (MCP-1) concentrations in conscious alveolar macrophage (AMØ)–depleted (solid circles) and intact (open circles) rats before and during 1 hour of breathing 10% O2. AMØ were depleted by tracheal instillation of clodronate-containing liposomes 4 days before the experiment. Intact rats received PBS-containing liposomes. Bars are 1 SE on either side of the mean, n = 5 rats per group for each data point. ***P < 0.01 versus corresponding normoxic control rats. §P < 0.01 versus corresponding value in intact rats. (B) Percentage of degranulated mast cells (MCs) after immersion in rat plasma. Peritoneal MCs (0.4 × 106 cells) from normoxic, intact rats were immersed in 0.4 ml of plasma obtained from rats depicted in A at times indicated in horizontal axis. Solid bars, AMØ-depleted rats; gray bars, intact rats. ***P < 0.01 versus corresponding normoxic control rats. §P < 0.01 versus corresponding value in intact rats.