Table II. The heterogeneity of anti-human CD8 antibodies.
Summary of the effects exerted by anti-human CD8 antibodies on pMHCI tetramer binding and CD8+ T-cell activation in the absence of TCR engagement.
| Ab Clone |
α or β |
Tetramer binding |
MIP1β | MIP1α | RANTES | IFNγ | TNFα | IL2 | Cyto toxicity |
|---|---|---|---|---|---|---|---|---|---|
| OKT8 | α | Enhance | Yes | Yes | Yes | No* | No* | No | Yes |
| SK1 | α | Inhibit | No | No | No | No | No | No | No |
| MCD8 | α | Neutral | No | No | No | No | No | No | No |
| 32/M4 | α | Neutral | No | No | No | No | No | No | No |
| C8/144B | α | Neutral | No | No | No | No | No | No | No |
| DK25 | α | Inhibit | No | No | No | No | No | No | No |
| 2ST8.5H7 | β | Inhibit | No | No | No | No | No | No | No |
*
OKT8 was shown to elicit IFNγ and TNFα release by SB10 and PHA/IL15-stimulated PBMC.