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. Author manuscript; available in PMC: 2011 Nov 15.
Published in final edited form as: J Immunol. 2011 Apr 1;186(10):5543–5547. doi: 10.4049/jimmunol.1003865

Figure 2. Endogenous leukocyte-derived microparticles contain resolvin precursors and LM pathway markers.

Figure 2

(A) MPs collected from zymosan (1mg i.p.) exudates and extracted for targeted lipidomics. LM biosynthetic pathway markers 17-HDHA (grey) and 14-HDHA (black) identified using scheduled MRM. (B) Representative mass spectrum of 17-HDHA within endogenous MPs. (C) Mice were administered d5-DHA (1μg i.v.) followed by zymosan (1mg i.p.) and MPs collected from 4h lavages. Both d5-17-HDHA and d5-14-HDHA were identified (transition pairs 348.2/245.1 and 348.2/205.1). Representative of n=3 per time point.