Table 2.

EFV median (IQR) plasma concentration in mg/L on and after antitubercular therapy with mean post-dose sampling times.

	On antitubercular therapy	After antitubercular therapy	p value
EFV 800/600 n=38	2.9 (1.8, 5.6)	2.1 (1.4, 3.0)	0.0003*
Proportion sub- therapeutic n (%)	1 (3%)	5 (13%)	0.089**
Mean post-dose sampling time: hours (+/− SD )	14.0 (1.5)	14.3 (1.7)	0.628#
EFV 600/600 n=34	2.4 (1.2, 5.1)	2.2 (1.4, 3.7)	0.669*
Proportion sub- therapeutic n (%)	4 (12%)	3 (9%)	0.690**
Mean post-dose sampling time: hours (+/− SD )	13.8 (1.7)	13.8 (1.8)	0.208#

Efavirenz therapeutic range: 1.0 –4.0 mg/L

^*Wilcoxon signrank test

^**Chi-squared test

^#t-test.