Table 2.
Predominant functional candidate genes studied in pre-eclampsia.
| Pathophysiological mechanism group | Gene name | Gene symbol | Predominant polymorphism investigated |
|---|---|---|---|
| Thrombophilia | Factor V Leiden | F5 | 506Gln>Arg |
| Methylenetetrahydrofolate | MTHFR | C667T | |
| Prothrombin | F2 | G20210A | |
| Plasminogen activator factor-1 | SERPINE1 | I/D promoter | |
| Integrin glycoprotein IIIa | GPIIIA | C98T | |
| Endothelial function | Endothelial nitric oxide synthase 3 | eNOS3 | 298Glu>Asp |
| Vascular endothelial growth factor receptor 1 | VEGFR1 | TG repeat | |
| Vascular endothelial growth factor | VEGF | C936T | |
| Vasoactive proteins | Angiotensinogen | AGT | 235Met>Thr |
| Angiotensin converting enzyme | ACE | I/D intron 16 | |
| Oxidative stress and lipid metabolism | Apolipoprotein E | APOE | C866T |
| Microsomal epoxide hydrolase | EPHX | 113Tyr>His | |
| Glutathione S-transferase | GST | A313G | |
| Immunogenetics | Tumor necrosis factor α | TNF | G-308A |
| Interleukin 10 | IL10 | G1082A |
I/D, insertion/dilution.