Table 3.
Minimal Inhibitory Concentrations (μg/ml) of Various Antimicrobials in Different Campylobacter Spp. and Their Isogenic cmeB Mutants
| Antimicrobials | C. jejuni 11168 | C. jejuni S3B | C. coli 993868 | C. coli TF1-13 | C. upsaliensis 2744 | C. lari 3121 | C. fetus 5652 |
|---|---|---|---|---|---|---|---|
| Ciprofloxacin | 0.25/0.031 (8) | 0.5/0.063 (8) | 0.25/0.031 (8) | 0.25/0.031 (8) | 0.5/0.063 (8) | 32/2 (16) | 1/0.0625 (16) |
| Erythromycin | 1/0.063 (16) | 1/0.031 (32) | 1/0.031 (32) | 256/4 (64) | 0.125/0.087 (16) | 2/0.031 (64) | 1/0.25 (4) |
| Ampicillin | 8/2 (4) | 16/1 (16) | 256/128 (2) | 16/8 (2) | 1/0.25 (4) | 2/0.125 (16) | 8/0.25 (4) |
| Cephalothin | 256/8 (32) | 256/4 (64) | 2048/32 (64) | 2048/8 (256) | 2/0.25 (8) | 128/0.5 (256) | 16/0.0625 (256) |
| Cefoperazone | 256/16 (16) | 1024/16 (64) | 2048/128 (16) | 1024/32 (32) | 16/0.063 (256) | 256/0.125 (2048) | 256/0.125 (2048) |
| Cefotaxime | 8/0.063 (128) | 16/0.063 (256) | 16/0.25 (64) | 16/0.063 (256) | 1/0.063 (16) | 32/0.063 (512) | 8/0.016 (512) |
| Rifampin | 256/1 (256) | 256/0.5 (512) | 64/0.0625 (1024) | 128/0.25 (512) | 8/0.063 (128) | 64/0.5 (128) | 128/128 (1) |
| Gentamicin | 2/1 (2) | 2/1 (2) | 1/0.5 (2) | 1/0.5 (2) | 8/8 (1) | 16/16 (1) | 32/32 (1) |
| Tetracycline | 0.125/0.063 (2) | 64/8 (8) | 0.5/0.125 (4) | 128/8 (16) | 1/0.125 (8) | 8/0.5 (16) | 8/0.5 (16) |
| Polymyxin B | 8/4 (2) | 4/2 (2) | 2/4 (0.5) | 2/4 (0.5) | 2/4 (0.5) | 4/8 (0.5) | >512/>512 (–) |
| Ethidium bromide | 1/0.125 (8) | 0.5/0.0625 (8) | 8/0.5 (16) | 4/0.25 (16) | 8/0.25 (32) | 4/1 (4) | 16/1 (16) |
| Cholic acid | 8192/128 (64) | 8192/128 (64) | 4096/256 (16) | 8192/256 (32) | 2048/32 (64) | 8192/32 (256) | 8192/128 (64) |
| Sodium dodecyl sulphate | 16/4 (4) | 32/4 (8) | 16/4 (4) | 32/8 (4) | 64/8 (8) | 256/8 (32) | 256/16 (16) |
Values indicate minimal inhibitory concentrations of the wild-type/its isogenic cmeB mutant. Values in bold are fold changes.