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(a) Plot of minimum vascular volume fraction vs axial pressure difference ΔP. [(b) and (c)] Plots of vascular diameter D and spacing H vs ΔP for the optimized models in (a). For all models, η=0.7 cP, L=2 cm,K=10−10 cm4∕dyn s, qO2=10−8 mol∕cm3 s, and kO2=1.2×10−9 mol∕cm3 mm Hg.