Fig. (2).

lncRNAs as inhibitors of transcription. lncRNAs expressed from anywhere in the genome can be packaged with transcript-specific proteins into functional lncRNPs (long non-coding ribonucleoproteins). The X, Y and Z ovals represent putative transcript-specific proteins associated with lncRNAs. lncRNPs could act locally or distally in cis, or in trans. Protein-coding genes are represented by orange, blue and green boxes. ncRNA gene is illustrated in grey. Transcription start sites (TSSs) are indicated by bent arrows, with thick arrows showing greater transcription activity. TSS of inhibited genes are indicated by thin bent arrows marked with an “X”. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this paper).