Table 2.
Putative Histone Modifiers Found in MAS Genomes
| Histone Modifiers | Residues Modified | Homologs in P.tricornutum | Homologs in T. pseudonana | Homologs in E. siliculosus |
|---|---|---|---|---|
| Lysine Acetyltransferases (KATs) | ||||
| HAT1 (KAT1) | H4 (K5, K12) | 54343 | 1397, 22580 | Esi0002_0151 |
| GCN5 (KAT2) | H3 (K9, K14, K18, K23, K36) | 46915 | 15161 | Esi0090_0053 |
| Nejire (KAT3); CBP/p300 (KAT3A/B) | H3 (K14, K18, K56) H4 (K5, K8); H2A (K5) H2B (K12, K15) | 45703, 45764, 54505 | 24331, 269496, 263785 | Esi0053_0101 |
| MYST1 (KAT8) | H4 (K16) | 24733, 24393 | 37928, 36275 | Esi0090_0053, Esi0084_0032 |
| ELP3 (KAT9) | H3 | 50848 | 9040 | Esi0264_0014 |
| Lysine Deacetylases (HDACs) | ||||
| RPD3 (Class I HDACS) | H2, H3, H4 | 51026, 49800 | 41025, 32098, 261393 | Esi0147_0031, Esi0181_0051, Esi0092_0077 |
| HDA1 (Class II HDACS) | H2, H3, H4 | 45906, 50482, 35869 | 268655, 269060, 3235, 15819 | Esi0168_0016, Esi0157_0055, Esi0157_0057, Esi0040_0047 |
| NAD+ dependant (Class III HDACS) | H4 (K16) | 52135, 45850, 24866, 45909, 52718, 21543, 39523 | 269475, 264809, 16405, 35693, 264494, 16384, 35956 | Esi0054_0036, Esi0014_0023, Esi0026_0040 |
| Lysine Methyltransferases | ||||
| MLL | H3 (K4) | 40183, 54436, 42693, 47328, 49473, 49476, 44935 | 35182, 35531, 22757 | Esi0069_0089 |
| ASH1/WHSC1 | H3 (K4) | 43275 | 264323 | Esi0016_0129, Esi0000_0259 |
| SETD1 | H3 (K36), H4 (K20) | not found | not found | Esi0070_0045, Esi0020_0054, Esi0043_0074 |
| SETD2 | H3 (K36) | 50375 | 35510 | Esi0028_0153 |
| SETDB1 | H3 (K9) | not found | not found | Esi0162_0064 |
| SETMAR | H3 (K4, K36) | not found | not found | Esi0100_0024 |
| SMYD | H3 (K4) | bd1647, 43708 | 23831, 24988 | Esi0013_0081, Esi0189_0013, Esi0189_0015, Esi0286_0007, Esi0015_0158 |
| TRX-related | not found | not found | Esi0115_0076, Esi0076_0098, Esi0043_0074, Esi0094_0082, Esi0455_0010 | |
| E(Z) | H3 (K9, K27) | 32817 | 268872 | not found |
| EHMT2 | H3 (K9, K27) | not found | not found | Esi0453_0004 |
| SET+JmjC | Unknown | bd1647 | not found | not found |
| Lysine Demethylases (KDM) | ||||
| LSD1 (KDM1) | H3 (K4, K9) | 51708, 44106, 48603 | not found | Esi0073_0073, Esi0060_0020, Esi0014_0196 |
| FBXL (KDM2) | H3 (K36) | 42595 | not found | Esi0025_0159 |
| JMJD2 (KDM4)/JARID | H3 (K9, K36) | 48747 | 2137 | Esi0145_0049, Esi0014_0020, Esi0084_0076 |
| JMJ-MBT | Unknown | 48109 | 22122 | not found |
| JMJ-CHROMO | Unknown | Pt1-40322 | 1863 | not found |
| Arginine Methyltransferases | ||||
| CARM1 (PRMT4) | H3 (R17) | 17184 | 3690, 28185 | Esi0137_0007, Esi0000_0236, Esi0165_0056 |
| PRMT5 | H3 (R8), H4 (R3) | 49565 | 24429 | Esi0006_0115 |
| PRMT6 | H3 (R2) | 54710 | bd1828 | Esi0153_0004, Esi0000_0300 |
| PRMT7 | H4 (R3) | 49245 | 25810 | Esi0133_0084, Esi0122_0102 |
| Arginine demethylases | ||||
| JMJD6 | H3 (R2), H4 (R3) | 3251, 35989, 46234 | 24024 | Esi0055_0014, Esi0131_0061, Esi0189_0080, Esi0055_0061 |
Proteins with putative histone modifier function were identified in the sets of predicted proteins from the MAS genomes by reverse BLAST comparison with enzymes known to catalyze the modification of specific histone residues (as indicated) and by searching for corresponding catalytic InterPro domains in MAS annotation databases. Candidate proteins are indicated by their identification number.