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Modulation of U-type inactivation in the S3-S4 linker mutants. Each panel shows the inactivation-voltage relationship of a given mutant channel recorded after pretreatment with DTT and/or MTSET. Each panel also shows the inactivation-voltage relationship of wt Kv2.1 and the mutant channel (shaded and dashed lines, respectively) recorded under control conditions for comparison. (Data points) Mean ± SE, connected by spline curves; n ≥ 3 for each test condition.
